By train
From Boston's North Station and Portland, Amtrak provides service on the "Downeaster" to the town of Wells, just north of Ogunquit.
By car
Interstate 95 is the direct route from Boston 1.25 hours and other east coast cities. When coming from the south, take Maine Exit 7 to Route 1 North for access to Ogunquit and The Yorks.
Interstate 95 throughout Maine and New Hampshire can experience major traffic jams from tourists traveling between the Boston metro area and vacation areas in the north. Using a EZ Pass or compatible transponder (http://en.wikipedia.org/w...) will avoid waiting in line at toll booths on 95. Using a GPS navigation system that can route you around traffic jams could also save a considerable amount of time, if you are not familiar with the area.
Route 1 is a viable coastal alternative to 95, and is also more scenic. Shore Road is even more coastal, connecting with Route 1 further south.
During the tourist season, Ogunquit experiences major traffic jams on Route 1 Main Street and Shore Road, centered around the intersection of the two roads. Public parking is in high demand and be quite expensive $25/day. See the Town of Ogunquit website (http://www.townofogunquit.org) for a map of available parking lots and rates. If driving, it is advisable to carpool if applicable, and determine where you would like to park in advance. Most overnight accommodations, like inns and resorts, provide their own free lots. Obed's Lot on Cottage Street requires advanced payment, which can be inconvenient if you do not know how long you wish to park, but which does allow you to leave without waiting in an exit line unlike the main Beach Lot.
Taking the Ogunquit Trolley between your parking lot and destinations of interest can be cost effective. Paid dedicated motorcycle parking is available in the main Beach Lot, and is underused compared to automobile parking. Taking public transit or parking outside of town and bicycling in would also avoid traffic hassles.
By bus
There is no intercity bus service direct to Ogunquit, however you can take the train to Wells, and then take the local trolley to Ogunquit.
C & J Trailways
(http://www.cjtrailways.com/), provide limo/bus service from Boston's Logan International Airport to their Portsmouth, NH terminal.Greyhound has service to Portland.